Heart remodeling causes the heart muscle to enlarge, especially during its relaxation (filling) phase. Remodeling also makes the heart rounder - more like a ball - which causes more heart wall stress. Mitral and tricuspid valve regurgitation may worsen this even more. This all leads to the heart needing more oxygen to function. It also leads to reduced blood flow. The heart's afterload may not match its preload, contributing to arrhythmias, sudden cardiac death, and heart failure.
http://www.chfpatients.com/faq/guidelines_ischemic.htm

Umkehr des Remodelingprozesses des Herzens
http://www.medtronic.ch/CH/downloadablefiles/CIRCULATION_Rev...

Anti-Remodeling Effekt
http://www.med.uni-giessen.de/sfb547/teilprojektuebersicht.h...

Antiproliferativer Effekt
http://www.kardiologiedresden.de/forschung/projekte.html

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Note added at 5 hrs 4 mins (2005-05-26 21:39:51 GMT)
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Reverse Remodeling
http://www.uni-muenster.de/Rektorat/Forschungsberichte-1999-...